Paradigms and paradoxes: Mouse (and human) models of genetic deafness

被引：13

作者：

Hughes, DC

机构：

[1] MRC Institute of Hearing Research, University of Nottingham, Nottingham, NG7 2RD, University park

来源：

AUDIOLOGY AND NEURO-OTOLOGY | 1997年 / 2卷 / 1-2期

关键词：

mouse; deafness; Kreisler; fibroblast growth factor; myosin; collagen; position effects;

D O I：

10.1159/000259224

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Mouse models have proved valuable tools in the analysis of human genetic disorders. The identification of the genes mutated in classical mouse mutants and the analysis of the phenotype of mutants following targeted gene disruption have provided some clarification of the development and functioning of the inner ear. A number of these genes also play a role in human deafness. Analysis of mutations in both human and mouse deafness genes has identified a number of distinct phenomena that contribute to the observed phenotype.

引用

页码：3 / 11

页数：9

共 44 条

[1] THE MOUSE SNELLS WALTZER DEAFNESS GENE ENCODES AN UNCONVENTIONAL MYOSIN REQUIRED FOR STRUCTURAL INTEGRITY OF INNER-EAR HAIR-CELLS [J].