FGF and genes encoding transcription factors in early limb specification

被引：56

作者：

Isaac, A

Cohn, MJ

Ashby, P

Ataliotis, P

Spicer, DB

Cooker, J

Tickle, C

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

[2] Univ Dundee, Dept Anat & Physiol, Dundee DD1 5EH, Scotland

[3] Univ Reading, Sch Anim & Microbial Sci, Div Zool, Reading RG6 6AJ, Berks, England

[4] UCL, Mol Cell Biol Lab, London WC1E 6BT, England

[5] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[6] Natl Inst Med Res, Dept Dev Neurobiol, London NW7 1AA, England

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 93卷 / 1-2期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

limb development; SnR; twist; fgf10; Tbx-5; Tbx-4; chick embryos; FGF-2; FGF-10;

D O I：

10.1016/S0925-4773(00)00261-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SnR, twist and Fgf10 are expressed in presumptive limb territories of early chick embryos. When FGF-2/FGF-8 beads are implanted in chick flank, an ectopic limb develops and SnR is irreversibly activated as early as 1 h. Ectopic Fgf10 and twist expression are activated much later at 17 and 20 h, respectively. FGF-10 can also induce SnR, but much later, and in this case activation occurs simultaneously with that of twist and Fgf10 via the Fgf8- expressing ridge. Tbx-C and Tbx-5 are expressed in leg and wing forming regions, respectively, in a similar pattern to SnR and twist. FGF-2 leads to ectopic expression of Tbx-l and Tbx-5 as rapidly as ectopic expression of SnR, but the patterns of ectopic transcripts suggest that induction of SnR and Tbx gene expression occur via different pathways. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 48

页数：8

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