Enzymatic resolution of alpha,beta-diacetoxysulfides: Synthesis of optically active O,S-acetals by regiospecific enantioselective primary acetate hydrolysis

被引：6

作者：

Brand, S

Jones, MF

Rayner, CM

机构：

[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

[2] GLAXO WELLCOME RES & DEV LTD,CHEM DEV,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(97)00672-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,beta-Diacetoxy sulphides are precursors of chiral oxathiolanes and have been resolved by Pseudomonas fluorescens lipase catalysed hydrolysis. The resolution proceeds with complete regioselectivity for the primacy acetate and excellent enantioselectivity in most cases. (C) 1997 Elsevier Science Ltd.

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页码：3595 / 3598

页数：4

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