Systems biology of stem cell fate and cellular reprogramming

被引：262

作者：

MacArthur, Ben D. ^{[1
,2
,3
]}

Ma'ayan, Avi ^{[3
]}

Lemischka, Ihor R. ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Black Family Stem Cell Inst, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, SBCNY, New York, NY 10029 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 10期

关键词：

TRANSCRIPTIONAL REGULATORY CIRCUITRY; SELF-RENEWAL; SIGNALING NETWORK; PROTEIN INTERACTIONS; POSITIVE-FEEDBACK; GENE-EXPRESSION; RNAI SCREEN; C-MYC; PLURIPOTENCY; MOUSE;

D O I：

10.1038/nrm2766

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These reports suggest that the control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular 'attractor' states towards which individual cells are drawn over time, whereas stochastic fluctuations in gene and protein expression levels drive transitions between coexisting attractors, ensuring robustness at the population level.

引用

页码：672 / 681

页数：10

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