Modulation of cellular function by polyamines

被引：640

作者：

Iarashi, Kazuei ^{[1
,2
]}

Kashiwagi, Keiko ^{[3
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan

[2] Amine Pharma Res Inst, Chuo Ku, Chiba 2600856, Japan

[3] Chiba Inst Sci, Fac Pharm, Chiba 2880025, Japan

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 01期

关键词：

Polyamine; Protein synthesis; Protein phosphorylation; NMDA receptor; Acrolein; D-ASPARTATE RECEPTOR; INITIATION-FACTOR; 5A; S-ADENOSYLMETHIONINE DECARBOXYLASE; OLIGOPEPTIDE-BINDING-PROTEIN; INTESTINAL EPITHELIAL-CELLS; SELECTIVE STRUCTURAL-CHANGE; PREFERENTIAL UPTAKE SYSTEM; SILENT BRAIN INFARCTION; TRANSFER-RNA FORMATION; RECTIFIER K+ CHANNELS;

D O I：

10.1016/j.biocel.2009.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The polyamine levels in cells are regulated by biosynthesis, degradation, and transport. Polyamines can modulate the functions of DNA, nucleotide triphosphates, proteins, and especially RNA because most polyamines exist in a polyamine-RNA complex in cells. Thus, the major focus on this review is on the role of polyamines in protein synthesis. In addition, effects of polyamines on B to Z conversion of DNA, transcription, phosphorylation of proteins, cell cycle progression, apoptosis and ion channels, especially NMDA receptors, are outlined. The function of eIF5A is also briefly discussed. Finally. a correlation between acrolein, produced from polyamines by polyamine oxidases, and chronic renal failure or brain stroke is summarized. Increased levels of polyamine oxidases and acrolein are good markers of chronic renal failure and brain stroke. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：39 / 51

页数：13

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