Effect of reducing caffeine intake on birth weight and length of gestation: randomised controlled trial

被引:75
作者
Bech, Bodil Hammer [1 ]
Obel, Carsten
Henriksen, Tine Brink
Olsen, Jorn
机构
[1] Aarhus Univ, Inst Publ Hlth, Dept Epidemiol, DK-8000 Aarhus, Denmark
[2] Aarhus Univ Hosp, Perinatal Epidemiol Res Unit, Skejby, Denmark
[3] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA
来源
BMJ-BRITISH MEDICAL JOURNAL | 2007年 / 334卷 / 7590期
关键词
D O I
10.1136/bmj.39062.520648.BE
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To estimate the effect of reducing caffeine intake during pregnancy on birth weight and length of gestation. Design Randomised double blind controlled trial. Setting Denmark. Participants 1207 pregnant women drinking at least three cups of coffee a day, recruited before 20 weeks' gestation. Interventions Caffeinated instant coffee (568 women) or decaffeinated instant coffee (629 women). Main outcome measures Birth weight and length of gestation. Results Data on birth weight were obtained for 1150 liveborn singletons and on length of gestation for 1153 liveborn singletons. No significant differences were found for mean birth weight or mean length of gestation between women in the decaffeinated coffee group (whose mean caffeine intake was 182 mg lower than that of the other group) and women in the caffeinated coffee group. After adjustment for length of gestation, parity, prepregnancy body mass index, and smoking at entry to the study the mean birth weight of babies born to women in the decaffeinated group was 16 g (95% confidence interval -40 to 73) higher than those born to women in the caffeinated group. The adjusted difference (decaffeinated group-caffeinated group) of length of gestation was -1.31 days (-2.87 to 0.25). Conclusion A moderate reduction in caffeine intake in the second half of pregnancy has no effect on birth weight or length of gestation.
引用
收藏
页码:409 / 412B
页数:6
相关论文
共 29 条
[1]  
ALDRIDGE A, 1979, CLIN PHARMACOL THER, V25, P447
[2]  
ALDRIDGE A, 1981, SEMIN PERINATOL, V5, P310
[3]   Caffeine consumption [J].
Barone, JJ ;
Roberts, HR .
FOOD AND CHEMICAL TOXICOLOGY, 1996, 34 (01) :119-129
[4]   CAFFEINE-CIGARETTE INTERACTION ON FETAL GROWTH [J].
BEAULACBAILLARGEON, L ;
DESROSIERS, C .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 157 (05) :1236-1240
[5]   Coffee and fetal death: A cohort study with prospective data [J].
Bech, BH ;
Nohr, EA ;
Vaeth, M ;
Henriksen, TB ;
Olsen, J .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 162 (10) :983-990
[6]   Association of maternal caffeine consumption with decrements in fetal growth [J].
Bracken, MB ;
Triche, EW ;
Belanger, K ;
Hellenbrand, K ;
Leaderer, BP .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (05) :456-466
[7]   Effect of caffeine exposure during pregnancy on birth weight and gestational [J].
Clausson, B ;
Granath, F ;
Ekbom, A ;
Lundgren, S ;
Nordmark, A ;
Signorello, LB ;
Cnattingius, S .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (05) :429-436
[8]   Caffeine intake and the risk of first-trimester spontaneous abortion. [J].
Cnattingius, S ;
Signorello, LB ;
Annerén, G ;
Clausson, B ;
Ekbom, A ;
Ljunger, E ;
Blot, WJ ;
McLaughlin, JK ;
Petersson, G ;
Rane, A ;
Granath, F .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (25) :1839-1845
[9]   Associations between maternal decaffeinated and caffeinated coffee consumption and fetal growth and gestational duration [J].
Eskenazi, B ;
Stapleton, AL ;
Kharrazi, M ;
Chee, WY .
EPIDEMIOLOGY, 1999, 10 (03) :242-249
[10]   CAFFEINE CONSUMPTION DURING PREGNANCY AND FETAL GROWTH [J].
FENSTER, L ;
ESKENAZI, B ;
WINDHAM, GC ;
SWAN, SH .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1991, 81 (04) :458-461