A novel subfamily of Hsp70s in the endoplasmic reticulum

被引：50

作者：

Craven, RA

Tyson, JR

Stirling, CJ

机构：

[1] School of Biological Sciences, University of Manchester, Manchester, M13 9PT, Oxford Road

来源：

TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 07期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S0962-8924(97)01079-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endoplasmic reticulum contains a number of proteins involved in the processing of secretory polypeptides. These include BiP, which is an Hsp70-family member highly conserved throughout evolution. BiP is known to be intimately involved in several aspects of protein biogenesis, but our understanding of these events has been complicated by the recent description of a novel Hsp70-related protein in yeast, Lhs1p, whose functions overlap with those of BiP. Current indications are that this protein is distributed widely among eukaryotes and that it represents a distinct subfamily of the Hsp70 class of molecular chaperones.

引用

页码：277 / 282

页数：6

共 51 条

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