Potential cardioprotective actions of no-releasing aspirin

被引：122

作者：

Wallace, JL ^{[1
]}

Ignarro, LJ

Fiorucci, S

机构：

[1] Univ Calgary, Dept Pharmacol & Therapeut, Calgary, AB T2N 4N1, Canada

[2] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90121 USA

[3] Univ Perugia, Dept Clin & Expt Med, I-06100 Perugia, Italy

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 05期

关键词：

D O I：

10.1038/nrd794

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of low doses of aspirin on a daily basis has increased greatly in the past 20 years, based on observations that it can significantly reduce the risk of heart attacks and strokes. However, aspirin can also cause severe damage to the stomach. A modified version of aspirin that releases nitric oxide has been developed that seems to offer important advantages over its 103-year-old parent - namely, improved protection for the heart without the unwanted effects on the stomach.

引用

页码：375 / 382

页数：8

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