Copper-Catalyzed Direct Alkenylation of N-Iminopyridinium Ylides

被引：145

作者：

Mousseau, James J. ^{[1
]}

Bull, James A. ^{[1
]}

Charette, Andre B. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

bioactivity; copper; heterocycles; homogeneous catalysis; vinylidene ligands; C-H BONDS; CROSS-COUPLING REACTIONS; DIRECT ARYLATION; HETEROAROMATIC-COMPOUNDS; SELECTIVE ALKENYLATION; OXIDES; PYRIDINE; BROMIDES; FUNCTIONALIZATION; MOLECULES;

D O I：

10.1002/anie.200906020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A versatile Cu-catalyzed direct C-H alkenylation of N-iminopyridinium ylides, compatible with several different copper sources (including a penny), provides a powerful and inexpensive method for the synthesis of functionalized pyridine derivatives. Chemoselective functionalization of halide-containing compounds allows the synthesis of alkenyl pyridines containing reactive tethers for further functionalization © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1115 / 1118

页数：4

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