Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

被引：113

作者：

Baldridge, JR ^{[1
]}

Yorgensen, Y ^{[1
]}

Ward, JR ^{[1
]}

Ulrich, JT ^{[1
]}

机构：

[1] RIBI Immunochem Res Inc, Hamilton, MT 59840 USA

来源：

VACCINE | 2000年 / 18卷 / 22期

关键词：

MPL; IgA; mucosal immunity;

D O I：

10.1016/S0264-410X(99)00572-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The induction of protective immunity stemming from vaccines delivered by mucosal routes is dependent on the development of safe and effective mucosal adjuvants. The immunostimulant monophosphoryl lipid A (MPL(R)) was evaluated for its ability to enhance both systemic and mucosal immunity to three distinct antigens. Vaccines formulated with MP(R) and hepatitis B surface antigen. tetanus toroid or influenza antigens were administered by intranasal delivery to mice. In each case the vaccines formulated with MPL(R) resulted in enhanced IgA titers from mucosal samples. Enhanced IgA concentrations were detected in samples from both local and distal mucosal sites. In addition, the MPL(R) formulated vaccines induced systemic immunity characteristic of a Thl-type of response. Serum IgG2a antibody titers were elevated and cytotoxic T cell activity was enhanced. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2416 / 2425

页数：10

共 39 条

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