Control of homeostasis of CD8+ memory T cells by opposing cytokines

被引：705

作者：

Ku, CC

Murakami, M

Sakamato, A

Kappler, J

Marrack, P

机构：

[1] Univ Colorado, Hlth Sci Ctr, Natl Jewish Med Ctr, Howard Hughes Med Inst,Dept Med, Denver, CO 80206 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80206 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Biol, Denver, CO 80206 USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80206 USA

[5] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

来源：

SCIENCE | 2000年 / 288卷 / 5466期

关键词：

D O I：

10.1126/science.288.5466.675

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Memory T cells maintain their numbers for long periods after antigen exposure, Here we show that CD8(+) T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2), Therefore, the numbers of CD8(+) memory T cells in animals are controlled by a balance between IL-15 and IL-2.

引用

页码：675 / 678

页数：4

共 45 条

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