Pitfalls in cefepime titration from human plasma: Plasma- and temperature-related drug degradation in vitro

被引：20

作者：

Bugnon, D ^{[1
]}

Giannoni, E ^{[1
]}

Majcherczyk, P ^{[1
]}

Glauser, MP ^{[1
]}

Moreillon, P ^{[1
]}

机构：

[1] CHU Vaudois, Div Infect Dis, Dept Internal Med, CH-1011 Lausanne, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期

关键词：

D O I：

10.1128/AAC.46.11.3654-3656.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degreesC but not at 4 degreesC. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.

引用

页码：3654 / 3656

页数：3

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