Sequencing the chimpanzee genome: Insights into human evolution and disease

被引：186

作者：

Olson, MV ^{[1
]}

Varki, A

机构：

[1] Univ Washington, Genome Ctr, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Genome Ctr, Dept Genome Sci, Seattle, WA 98195 USA

[3] Univ Calif San Diego, Dept Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1038/nrg981

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Large-scale sequencing of the chimpanzee genome is now imminent. Beyond the inherent fascination of comparing the sequence of the human genome with that of our closest living relative, this project is likely to yield tangible scientific benefits in two areas. First, the discovery of functionally important mutations that are specific to the human lineage offers a new path towards medical benefits. Second, chimpanzee-human comparisons are likely to yield molecular insights into how new biological characteristics evolve - findings that might be relevant throughout the tree of life.

引用

页码：20 / 28

页数：9

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