Towards multistep nanostructure synthesis: Programmed enzymatic self-assembly of DNA/gold systems

被引：153

作者：

Kanaras, AG

Wang, ZX

Bates, AD

Cosstick, R

Brust, M ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Ctr Nanoscale Sci, Liverpool L69 7ZD, Merseyside, England

[2] Univ Liverpool, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 02期

关键词：

DNA; enzymes; gold; nanostructures; self-assembly;

D O I：

10.1002/anie.200390075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzyme-dependent assembly of DNA/gold nanostructures is achieved using DNA-capped gold colloids and DNA processing enzymes. Particle-bound DNA double strands are cleaved at designated sites by a restriction endonuclease (see picture). In a subsequent step the particles are linked to each other through these activated sites by a DNA ligase. This new strategy enables the multistep synthesis of nanostructures.

引用

页码：191 / +

页数：5

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