Augur - a computational pipeline for whole genome microbial surface protein prediction and classification

被引:27
作者
Billion, A. [1 ]
Ghai, R. [1 ]
Chakraborty, T. [1 ]
Hain, T. [1 ]
机构
[1] Univ Giessen, Inst Med Microbiol, D-35392 Giessen, Germany
关键词
D O I
10.1093/bioinformatics/btl466
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The analysis of protein function is a challenge and a major bottleneck towards well-annotated and analysed microbial genomes. In particular, bacterial surface proteins present an opportunity for pharmacological intervention and vaccine development. We present Augur, an automatic prediction pipeline that integrates major surface prediction algorithms and enables comparative analysis, classification and visualization for gram-positive bacteria on a genomic scale. Availability: http://bioinfo.mikrobio.med.uni-giessen.de/augur Contact: Andre. Billion@mikrobio.med.uni-giessen.de Supplementary information: Supplementary data are available at Bioinformatics online.
引用
收藏
页码:2819 / 2820
页数:2
相关论文
共 11 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]  
Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkr1065, 10.1093/nar/gkh121]
[3]   Surface proteins and the pathogenic potential of Listeria monocytogenes [J].
Cabanes, D ;
Dehoux, P ;
Dussurget, O ;
Frangeul, L ;
Cossart, P .
TRENDS IN MICROBIOLOGY, 2002, 10 (05) :238-+
[4]   Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes [J].
Krogh, A ;
Larsson, B ;
von Heijne, G ;
Sonnhammer, ELL .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 305 (03) :567-580
[5]   The SUPERFAMILY database in 2004: additions and improvements [J].
Madera, M ;
Vogel, C ;
Kummerfeld, SK ;
Chothia, C ;
Gough, J .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D235-D239
[6]  
MURZIN AG, 1995, J MOL BIOL, V247, P536, DOI 10.1016/S0022-2836(05)80134-2
[7]   PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization [J].
Nakai, K ;
Horton, P .
TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (01) :34-35
[8]   Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites [J].
Nielsen, H ;
Engelbrecht, J ;
Brunak, S ;
vonHeijne, G .
PROTEIN ENGINEERING, 1997, 10 (01) :1-6
[9]   Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome [J].
Rodríguez-Ortega, MJ ;
Norais, N ;
Bensi, G ;
Liberatori, S ;
Capo, S ;
Mora, M ;
Scarselli, M ;
Doro, F ;
Ferrari, G ;
Garaguso, I ;
Maggi, T ;
Neumann, A ;
Covre, A ;
Telford, JL ;
Grandi, G .
NATURE BIOTECHNOLOGY, 2006, 24 (02) :191-197
[10]   Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes [J].
Sutcliffe, IC ;
Harrington, DJ .
MICROBIOLOGY-SGM, 2002, 148 :2065-2077