Adherence to antimicrobal inhalational anthrax prophylaxis among postal workers, Washington, DC, 2001

被引:49
作者
Jefferds, MD [1 ]
Laserson, K [1 ]
Fry, AM [1 ]
Roy, S [1 ]
Hayslett, J [1 ]
Grummer-Strawn, L [1 ]
Kettel-Khan, L [1 ]
Schuchat, A [1 ]
机构
[1] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA
关键词
D O I
10.3201/eid0810.020331
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In October 2001, two envelopes containing Bacillus anthracis spores were processed at the Washington, D.C., Processing and Distribution Center of the U.S. Postal Service; inhalational anthrax developed in four workers at this facility. More than 2,000 workers were advised to complete 60 days of postexposure prophylaxis to prevent inhalational anthrax. Interventions to promote adherence were carried out to support workers, and qualitative information was collected to evaluate our interventions. A quantitative survey was administered to a convenience sample of workers to assess factors influencing adherence. No anthrax infections developed in any workers involved in the interventions or interviews. Of 245 workers, 98 (40%) reported full adherence to prophylaxis, and 45 (18%) had completely discontinued it. Anxiety and experiencing adverse effects to prophylaxis, as well as being <45 years old were risk factors for discontinuing prophylaxis. Interventions, especially frequent visits by public health staff, proved effective in supporting adherence.
引用
收藏
页码:1138 / 1144
页数:7
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