Preparation of tetra-Boc-protected polymyxin B nonapeptide

被引：21

作者：

O'Dowd, Hardwin ^{[1
]}

Kim, Bum ^{[1
]}

Margolis, Peter ^{[1
]}

Wang, Wen ^{[1
]}

Wu, Charlotte ^{[1
]}

Lopez, Sara L. ^{[1
]}

Blais, Johanne ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Fremont, CA 94555 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 11期

关键词：

D O I：

10.1016/j.tetlet.2007.01.071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the selective tetra-Boc-protection of polymyxin B nonapeptide (PMBN) has been developed. Boc-ON selectively protects the amino side chains of the four diaminobutyric acid (Dab) residues in the presence of the N-terminal free amine. (c) 2007 Published by Elsevier Ltd.

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页码：2003 / 2005

页数：3

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