Peptide antibiotics

被引：945

作者：

Hancock, REW

机构：

[1] Dept. of Microbiology and Immunology, University of British Columbia, Vancouver

来源：

LANCET | 1997年 / 349卷 / 9049期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(97)80051-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The era of the ''classical antibiotic'' may be over. The emergence of resistance has seen to that. Yet no truly novel class of antibacterial agent has come on the market in the past 30 years. Currently there is great interest in peptide antibiotics, especially the cationic peptides. Thousands of such molecules have been synthesised and just a few are entering clinical trials. Because they kill bacteria quickly by the physical disruption of cell membranes, peptide antibiotics may not face the rapid emergence of resistance.

引用

收藏

页码：418 / 422

页数：5

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