Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C

被引：56

作者：

Norton, PM ^{[1
]}

Wells, JM ^{[1
]}

Brown, HWG ^{[1
]}

Macpherson, AM ^{[1
]}

LePage, RWF ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QP,ENGLAND

来源：

VACCINE | 1997年 / 15卷 / 6-7期

关键词：

intranasal immunization; Lactococcus lactis; tetanus toxin; vaccine; mucosal immunization;

D O I：

10.1016/S0264-410X(96)00241-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody responses. There was no requirement for either colonization or invasion of the mucosa. In addition secretory antibody responses in the lung and nasal tissues were elicited after i.n. inoculation tit the presence of an adjuvant. (C) 1997 Elsevier Science Ltd.

引用

页码：616 / 619

页数：4

共 16 条

[1] HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES TO LIVE RECOMBINANT BCG-HIV VACCINES [J].