Autoantibodies against a kidney - liver protein associated with quinolone-induced acute interstitial nephritis or hepatitis

被引：5

作者：

Gauffre, A

Mircheva, J

Glotz, D

Fillastre, JP

Simon, P

Beaune, PH

Druet, P

机构：

[1] UNIV PARIS 05,CHU NECKER,INSERM,U75,F-75730 PARIS 15,FRANCE

[2] HOP BROUSSAIS,INSERM,U28,F-75674 PARIS,FRANCE

[3] HOP BOIS GUILLAUME,BOIS GUILLAUME,FRANCE

[4] CTR HOSP ST BRIEUC,ST BRIEUC,FRANCE

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 1997年 / 12卷 / 09期

关键词：

quinolone; acute interstitial nephritis; hepatitis; autoantibodies; P-450;

D O I：

10.1093/ndt/12.9.1961

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

In the present study we report on four cases of acute interstitial nephritis (AIN) and two cases of hepatitis induced by quinolone. We show by immunoblotting analysis that all sera from these patients contained autoantibodies that recognize a 65-kDa protein expressed in normal human kidney and liver microsomes. Only 6% of sera from healthy individuals who did not ingest quinolone recognized the same protein. These findings suggest that the presence of autoantibodies could be used as a sensitive marker and that a modification of microsomal proteins by quinolone itself or by a metabolite could generated an autoimmune response.

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收藏

页码：1961 / 1962

页数：2

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