The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1β in rat cortical synaptosomes

被引：9

作者：

Campbell, V ^{[1
]}

Lynch, MA ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland

来源：

CYTOKINE | 2000年 / 12卷 / 05期

关键词：

ceramide; intracellular free Ca2+; interleukin; 1; beta; synaptosomes; mitogen-activated protein kinase;

D O I：

10.1006/cyto.1999.0584

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We recently demonstrated that the are-inflammatory cytokine, interleukin 1 beta (IL-1 beta) elevates intracellular free Ca2+ levels ([Ca2+](i)) in rat cortical synaptosomes in a manner involving activation of the IL-1 receptor and stimulation of p42 mitogen-activated protein (MAP) kinase, We now report that the effects of IL-1 beta on [Ca2+](i) are mimicked by the sphingolipid metabolite ceramide, In cortical synaptosomes ceramide elevates [Ca2+](i) in a p42 MAP kinase-dependent manner, and we conclude that the effects of IL-1 beta on Ca2+ homeostasis involve ceramide as an upstream component of the p42 MAP kinase pathway. (C) 2000 Academic Press.

引用

页码：487 / 490

页数：4

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