Wnt signaling in the vessel wall

被引:30
作者
Badimon, Lina [1 ,2 ]
Borrell-Pages, Maria [1 ]
机构
[1] Inst Carlos III, IIB St Pau & CIBERCV, Cardiovasc Res Ctr CSIC ICCC, Barcelona, Spain
[2] UAB, Cardiovasc Res Chair, Barcelona, Spain
关键词
atherosclerosis; low-density lipoprotein receptor-related protein 5; vessel wall; Wnt signaling; RECEPTOR-RELATED PROTEIN-5; MUSCLE-CELL PROLIFERATION; PLURIPOTENT STEM-CELLS; TRANSCRIPTION FACTOR; ENDOTHELIAL-CELLS; BREAST-CANCER; VALVE DISEASE; BETA-CATENIN; INHIBITS WNT; PATHWAY;
D O I
10.1097/MOH.0000000000000336
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Purpose of review Wnt signaling plays a crucial role during embryogenesis. In an adult, Wnt is mainly associated to cellular proliferation and differentiation mechanisms. Recent data suggest that Wnt signaling is involved in the pathophysiology of atherosclerosis. However, the roles of Wnt signaling pathways in the vessel wall are poorly understood. This review outlines recent discoveries in understanding the role of Wnt pathways in healthy and atherosclerotic vessels. Recent findings In the last years, the involvement of both canonical and noncanonical Wnt pathways in the development of atherosclerotic lesions has been recognized. Indeed, several Wnt pathway components have been shown to participate in the early, intermediate, and late stages of atherosclerosis development. Specifically, the role of the Wnt coreceptors low-density lipoprotein receptor-related protein 5 and low-density lipoprotein receptor-related protein 6 seems to be crucial for atherosclerotic plaque progression. Summary Many of the clinical trials developed in the last decade to reduce atherosclerosis and cardiovascular diseases have been futile or have failed possibly because of a poor understanding of new mechanisms that lead to diseases. The understanding of the signaling pathways involved in human atherosclerosis development should help in the development of future therapies.
引用
收藏
页码:230 / 239
页数:10
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