Efficacy of oxcarbazepine for prophylaxis against cumulative oxaliplatin-induced neuropathy

被引：85

作者：

Argyriou, A. A. ^{[1
]}

Chroni, E.

Polychronopoulos, P.

Iconomou, G.

Koutras, A.

Makatsoris, T.

Gerolymos, M. K.

Gourzis, P.

Assimakopoulos, K.

Kalofonos, H. P.

机构：

[1] Univ Patras, Sch Med, Dept Neurol, EMG ENG Lab, Rion 26504, Greece

[2] Univ Patras, Sch Med, Dept Med, Div Oncol, Rion 26504, Greece

来源：

NEUROLOGY | 2006年 / 67卷 / 12期

关键词：

D O I：

10.1212/01.wnl.0000249344.99671.d4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We conducted a randomized, open-label, controlled trial to assess the efficacy of oxcarbazepine for prophylaxis against oxaliplatin-induced peripheral neuropathy (OxIN). Thirty-two patients with colon cancer received 12 courses of the FOLFOX-4 regimen and were randomly assigned to receive oxcarbazepine (600 mg BID) or chemotherapy without oxcarbazepine. The incidence of OxIN was strikingly decreased in patients receiving oxcarbazepine (31.2% vs 75%). Oxcarbazepine may prevent OxIN symptoms. Further larger placebo- controlled trials are warranted to confirm our results.

引用

页码：2253 / 2255

页数：3

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