Ischaemic preconditioning of the vasculature: an overlooked phenomenon for protecting the heart

被引：72

作者：

Rubino, A ^{[1
]}

Yellon, DM ^{[1
]}

机构：

[1] UCL Hosp, Hatter Inst Cardiovasc Studies, London WC1E 6DB, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0165-6147(00)01483-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Exposing the heart to brief episodes of ischaemia protects the myocardium and vascular endothelial cells against functional damage and cell death caused by subsequent prolonged ischaemia. Elucidation of the mechanisms that are involved in this phenomenon known as 'ischaemic preconditioning' and identification of drugs that mimic the protective response have the potential to improve the prognosis of myocardial infarction and other cardiac syndromes dramatically. This article focuses on recent findings on the effects of ischaemic preconditioning of the coronary vasculature, which highlight the endothelium as an important target for a successful therapeutic approach to myocardial ischaemia-reperfusion injury.

引用

页码：225 / 230

页数：6

共 42 条

[1] B1 receptors as a new inflammatory target.: Could this B the 1? [J].

Ahluwalia, A ;

Perretti, M .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (03) :100-104

[2] Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: Implications for myocardial protection [J].

Amrani, M ;

Latif, N ;

Morrison, K ;

Gray, CC ;

Jayakumar, J ;

Corbett, J ;

Goodwin, AT ;

Dunn, MJ ;

Yacoub, MH .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, 115 (01) :200-209

[3] Protective effects of preconditioning in cultured rat endothelial cells - Effects on neutrophil adhesion and expression of ICAM-1 after anoxia and reoxygenation [J].

Beauchamp, P ;

Richard, V ;

Tamion, F ;

Lallemand, F ;

Lebreton, JP ;

Vaudry, H ;

Daveau, M ;

Thuillez, C .

CIRCULATION, 1999, 100 (05) :541-546

[4] Stress (heat shock) proteins - Molecular chaperones in cardiovascular biology and disease [J].

Benjamin, IJ ;

McMillan, DR .

CIRCULATION RESEARCH, 1998, 83 (02) :117-132

[5] Delayed preconditioning with adenosine is mediated by opening of ATP-sensitive K+ channels in rabbit heart [J].

Bernardo, NL ;

Okubo, S ;

Maaieh, MM ;

Wood, MA ;

Kukreja, RC .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (01) :H128-H135

[6] Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide [J].

Bolli, R ;

Bhatti, ZA ;

Tang, XL ;

Qiu, YM ;

Zhang, Q ;

Guo, Y ;

Jadoon, AK .

CIRCULATION RESEARCH, 1997, 81 (01) :42-52

[7] Role of kinins in the endothelial protective effect of ischaemic preconditioning [J].

Bouchard, JF ;

Chouinard, J ;

Lamontagne, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (03) :413-420

[8]

BOUCHARD JF, 1996, AM J PHYSIOL, V40, pH1801

[9] Myocardial adaptation to ischaemia - the preconditioning phenomenon [J].

Carroll, R ;

Yellon, DM .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1999, 68 :S93-S101

[10]

Dana A, 1998, CARDIOVASC DRUG THER, V12, P515

← 1 2 3 4 5 →