The bioethics of stem cell research and therapy

被引：109

作者：

Hyun, Insoo ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Bioeth, Cleveland, OH 44106 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 01期

关键词：

ALTERED NUCLEAR TRANSFER; GENERATION;

D O I：

10.1172/JCI40435

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Discussion of the bioethics of human stem cell research has transitioned from controversies over the source of human embryonic stem cells to concerns about the ethical use of stem cells in basic and clinical research. Key areas in this evolving ethical discourse include the derivation and use of other human embryonic stem cell-like stem cells that have the capacity to differentiate into all types of human tissue and the use of all types of stem cells in clinical research. Each of these issues is discussed as I summarize the past, present, and future bioethical issues in stem cell research.

引用

页码：71 / 75

页数：5

共 31 条

[1] Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges [J].

Aalto-Setaelae, Katriina ;

Conklin, Bruce R. ;

Lo, Bernard .

PLOS BIOLOGY, 2009, 7 (02) :204-208

[2]

[Anonymous], GUID HUM EMBR STEM C

[3]

[Anonymous], WHIT PAP ALT SOURC H

[4] Producing primate embryonic stem cells by somatic cell nuclear transfer [J].

Byrne, J. A. ;

Pedersen, D. A. ;

Clepper, L. L. ;

Nelson, M. ;

Sanger, W. G. ;

Gokhale, S. ;

Wolf, D. P. ;

Mitalipov, S. M. .

NATURE, 2007, 450 (7169) :497-U3

[5] The Stem Cell Research Environment: A Patchwork of Patchworks [J].

Caulfield, Timothy ;

Zarzeczny, Amy ;

McCormick, Jennifer ;

Bubela, Tania ;

Critchley, Christine ;

Einsiedel, Edna ;

Galipeau, Jacques ;

Harmon, Shawn ;

Huynh, Michael ;

Hyun, Insoo ;

Illes, Judy ;

Isasi, Rosario ;

Joly, Yann ;

Laurie, Graeme ;

Lomax, Geoff ;

Longstaff, Holly ;

McDonald, Michael ;

Murdoch, Charles ;

Ogbogu, Ubaka ;

Owen-Smith, Jason ;

Pattinson, Shaun ;

Premji, Shainur ;

von Tigerstrom, Barbara ;

Winickoff, David E. .

STEM CELL REVIEWS AND REPORTS, 2009, 5 (02) :82-88

[6] Cdx2 is essential for axial elongation in mouse development [J].

Chawengsaksophak, K ;

de Graaff, W ;

Rossant, J ;

Deschamps, J ;

Beck, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (20) :7641-7645

[7] Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres [J].

Chung, Y ;

Klimanskaya, I ;

Becker, S ;

Marh, J ;

Lu, SJ ;

Johnson, J ;

Meisner, L ;

Lanza, R .

NATURE, 2006, 439 (7073) :216-219

[8]

Cohen C.B., 2007, RENEWING STUFF LIFE

[9]

Cosgrove Delos M, 2008, Cleve Clin J Med, V75 Suppl 6, pS6

[10] Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos [J].

Eiges, Rachel ;

Urbach, Achia ;

Malcov, Mira ;

Frumkin, Tsvia ;

Schwartz, Tamar ;

Amit, Ami ;

Yaron, Yuval ;

Eden, Amir ;

Yanuka, Ofra ;

Benvenisty, Nissim ;

Ben-Yosef, Dalit .

CELL STEM CELL, 2007, 1 (05) :568-577

← 1 2 3 4 →