Mechanism of Action of Homocysteine and Its Thiolactone in Hemostasis System

被引：51

作者：

Karolczak, K. ^{[1
]}

Olas, B. ^{[1
]}

机构：

[1] Univ Lodz, Dept Gen Biochem, Inst Biochem, Banacha 12-16, PL-90237 Lodz, Poland

来源：

PHYSIOLOGICAL RESEARCH | 2009年 / 58卷 / 05期

关键词：

Homocysteine; Homocysteine thiolactone; Hemostasis; NITRIC-OXIDE; PLATELET ACTIVATION; PROTEIN; FIBRIN; ACID; HYPERHOMOCYSTEINEMIA; GENERATION; THROMBOSIS; DISEASE; RISK;

D O I：

10.33549/physiolres.931566

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In the article, the actions of homocysteine (Hcys) and its metabolite - cyclic thioester - homocysteine thiolactone (HTL) on complex process of hemostasis, which regulates the flowing properties of blood, are described. Possible interaction of Hcys and HTL with endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, as the important major components of hemostasis are also discussed. The modification of hemostatic proteins (N-homocysteinylated or S-homocysteinylated proteins) induced by Hcys or its thiolactone, and links of homocysteine or homocysteine thiolactone to (NO)-N-center dot metabolism seem to be the main reason of biotoxicty of homocysteine in cardiovascular diseases.

引用

页码：623 / 633

页数：11

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