Harsh Reaction Conditions in Continuous-Flow Microreactors for Pharmaceutical Production

被引：120

作者：

Kockmann, Norbert ^{[1
]}

Roberge, Dominique M. ^{[1
]}

机构：

[1] Lonza AG, R&D Exclus Synth, Proc Res, CH-3930 Visp, Switzerland

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2009年 / 32卷 / 11期

关键词：

Microreactors; Organic materials; Process engineering; Safety management; MICROSTRUCTURED DEVICES; TRANSFER RATES; PRACTICAL USE; CHEMISTRY; MASS; TECHNOLOGY; GENERATION; DESIGN; SCALE; HEAT;

D O I：

10.1002/ceat.200900355

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Enhanced transport phenomena are essential for chemical reactions in continuous-flow microstructured equipment with transitional flow regimes. The geometry and cross-section of the smallest channel determines the flow regime, pressure loss, and energy dissipation in the microchannel. Mixing and heat transfer are greatly influenced by the flow regime. Controlled reaction conditions lead to enhanced safety, especially for harsh reaction conditions at elevated temperatures or high concentrations. Safety and operational limits of these regimes are presented for optimized process intensification, with examples of nitration and organometallic reactions.

引用

页码：1682 / 1694

页数：13

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