Modulation of temperature-sensitive TRP channels

被引：107

作者：

Huang, Jiehong ^{[1
]}

Zhang, Xuming ^{[1
]}

McNaughton, Peter A. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2006年 / 17卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

sensory transduction; thermal sensation; protein kinase; intracellular signalling;

D O I：

10.1016/j.semcdb.2006.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Animals sense temperature - either cold or hot - by the direct activation of temperature-sensitive members of the TRP family of ion channels, the thermo-TRPs. To date, six TRP channels - TRPV1-4, TRPM8 and TRPA1 - have been reported to be directly activated by heat and to be involved in thermosensation. Temperature sensing can be modulated by phosphorylation of intracellular residues by protein kinases or by insertion of new channels into the cell membrane. In this review we provide a brief overview of the properties of thermo-TRPs, and we summarise signalling pathways involved in their regulation. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：638 / 645

页数：8

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