Pexophagy: Autophagic degradation of peroxisomes

被引：174

作者：

Sakai, Yasuyoshi ^{[1
]}

Oku, Masahide

van der Klei, Ida J.

Kiel, Jan A. K. W.

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 6068502, Japan

[2] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Eukaryotic Microbiol, NL-9750 AA Haren, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 12期

关键词：

ATG gene; autophagy; peroxin; pexophagy; sequestration; vacuole; YEAST HANSENULA-POLYMORPHA; VACUOLE TARGETING PATHWAY; PICHIA-PASTORIS REQUIRES; COILED-COIL PROTEIN; SACCHAROMYCES-CEREVISIAE; SELECTIVE AUTOPHAGY; YARROWIA-LIPOLYTICA; INDUCED MICROAUTOPHAGY; MEMBRANE-STRUCTURE; GENE ENCODES;

D O I：

10.1016/j.bbamcr.2006.08.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The abundance of peroxisomes within a cell can rapidly decrease by selective autophagic degradation (also designated pexophagy). Studies in yeast species have shown that at least two modes of peroxisome degradation are employed, namely macropexophagy and micropexophagy. During macropexophagy, peroxisomes are individually sequestered by membranes, thus fort-ning a pexophagosome. This structure fuses with the vacuolar membrane, resulting in exposure of the incorporated peroxisome to vacuolar hydrolases. During micropexophagy, a cluster of peroxisomes is enclosed by vacuolar membrane protrusions and/or segmented vacuoles as well as a newly formed membrane structure, the micropexophagy-specific membrane apparatus (MIPA), which mediates the enclosement of the vacuolar membrane. Subsequently, the engulfed peroxisome cluster is degraded. This review discusses the current state of knowledge of pexophagy with emphasis on studies on methylotrophic yeast species. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1767 / 1775

页数：9

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