A simple and facile method for the synthesis of novel 5/7 trifluoromethyl-substituted 4(3H)-quinazolone regioisomers

被引：25

作者：

Maitraie, D ^{[1
]}

Reddy, GV ^{[1
]}

Rao, VVVNS ^{[1
]}

Kanth, SR ^{[1
]}

Rao, PS ^{[1
]}

Narsaiah, B ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 2, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2002年 / 118卷 / 1-2期

关键词：

2,6-dicyanoanilines; dicarboxamido anilines; 4(3H)-quinazolones;

D O I：

10.1016/S0022-1139(02)00194-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The unsymmetrical 1,3-diketones 1 on reaction with malononitrile is resulted an interesting trifunctional intermediates 2 and 3. The intermediate 2 is hydrolyzed to give 2,6-dicarboxamido aniline 4 which on cyclisation gave two regioisomers of 1,2-dihydro-4(3H)quinazolinones 5 and 6. The effect of substituents on compound 4 is characteristic for formation of regioisomers in different proportions. Each regioisomer on dehydrogenation under mild condition using active MnO2 gave corresponding 4(3H)-quinazolones 7 and 8, respectively. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：73 / 79

页数：7

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