ARID proteins come in from the desert

被引：152

作者：

Kortschak, RD ^{[1
]}

Tucker, PW

Saint, R

机构：

[1] Univ Adelaide, Ctr Thef Mol Genet Dev, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Dept Genet, Adelaide, SA 5005, Australia

[3] Univ Texas, Dept Microbiol, Austin, TX 78712 USA

[4] Univ Texas, Inst Cellular & Mol Biol, Austin, TX 78712 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(00)01597-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.

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页码：294 / 299

页数：6

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