The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes

被引：58

作者：

Beaulieu, Lea M. ^{[1
]}

Freedman, Jane E. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Dept Med, Boston, MA 02118 USA

来源：

THROMBOSIS RESEARCH | 2010年 / 125卷 / 03期

关键词：

Platelets; Toll-like Receptors; Megakaryocytes; TLR2; TLR4; ESCHERICHIA-COLI; IN-VIVO; CHLAMYDIA-PNEUMONIAE; POSSIBLE INVOLVEMENT; MEMBRANE-VESICLES; BLOOD-PLATELETS; AGGREGATION; LIPOPOLYSACCHARIDE; ACTIVATION; TLR4;

D O I：

10.1016/j.thromres.2009.11.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets have been extensively studied as hemostatic regulators, stopping uncontrolled flow of blood from an injured vessel and allowing for repair. However, multiple studies have shown that platelets can interact with bacterial proteins, particularly seen during sepsis and inflammation. Immune cells recognize pathogens through Toll-like Receptors (TLRs). These same receptors allow platelets to recognize bacterial proteins and regulate platelet immunity and function. This review examines the TLRs expressed on platelets and megakaryocytes and how these receptors affect the function of these cells. Through TLRs, platelets go beyond hemostatic regulation and play a pivotal role in inflammation and infection. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：205 / 209

页数：5

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