Current concepts in AIDS pathogenesis: Insights from the SIV/macaque model

被引：95

作者：

Lackner, Andrew A. ^{[1
]}

Veazey, Ronald S. ^{[1
]}

机构：

[1] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2007年 / 58卷

关键词：

mucosal immune system; HIV/SIV transmission; cellular targets of HIV/SIV infection; acute HIV/SIV infection;

D O I：

10.1146/annurev.med.58.082405.094316

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pathogenesis of AIDS has proven to be quite complex and dynamic, with most of the critical events (e.g., transmission, CD4+ T cell destruction) occurring in tissues that are not easily accessible for analysis. In addition, although the disease can progress over years, many critical events happen within the first few weeks of infection, when most patients are unaware that they are infected. The nonhuman primate model of AIDS has been used extensively to fill these gaps in our understanding of AIDS pathogenesis.

引用

页码：461 / 476

页数：20

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