Aminoglycosides and other factors promoting stop codon readthrough in human cells

被引：22

作者：

Diop, Dialo

Chauvin, Celine

Jean-Jean, Olivier

机构：

[1] Univ Paris 06, CNRS, Unite Biochim Cellulaire, UMR 7098, F-75252 Paris 05, France

[2] Univ Cheick Anta Diop, Fac Med & Pharm, Dakar, Senegal

来源：

COMPTES RENDUS BIOLOGIES | 2007年 / 330卷 / 01期

关键词：

aminoglycosides; genetic diseases; translational readthrough; stop codons; termination factors eRF1 and eRF3a;

D O I：

10.1016/j.crvi.2006.09.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Enhanced stop codon readthrough is a potential treatment strategy for diseases caused by nonsense mutations. Here, we compare readthrough levels induced by three types of factors: aminoglycoside antibiotics, suppressor tRNAs, and factors decreasing translation termination efficiency. We show that the highest levels of readthrough were obtained by prolonged treatment with amino-glycosides and suppressor tRNAs, whereas prolonged depletion of release factors induced only a moderate increase in readthrough. We discuss the benefits and inconvenients of the three types of factors for their use in the therapy of diseases caused by premature stop codons.

引用

收藏

页码：71 / 79

页数：9

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