Drug and gene delivery to the brain: The vascular route

被引:316
作者
Pardridge, WM [1 ]
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA
关键词
D O I
10.1016/S0896-6273(02)01054-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain drug development of either small molecule or large molecule (recombinant proteins, gene medicines) neurotherapeutics has been limited, owing to the restrictive transport properties of the brain microvasculature, which forms the blood-brain barrier (BBB) in vivo. Widespread drug delivery to the brain, while not feasible via craniotomy and intracerebral injection, is possible if the drug is delivered to brain via the transvascular route through the BBB. Novel brain drug delivery and drug targeting strategies can be developed from an understanding of the molecular and cellular biology of the brain microvascular and BBB transport processes.
引用
收藏
页码:555 / 558
页数:4
相关论文
共 22 条
  • [1] Designing libraries with CNS activity
    Ajay
    Bemis, GW
    Murcko, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (24) : 4942 - 4951
  • [2] Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2
    Asaba, H
    Hosoya, K
    Takanaga, H
    Ohtsuki, S
    Tamura, E
    Takizawa, T
    Terasaki, T
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 75 (05) : 1907 - 1916
  • [3] Bar T., 1980, ADV ANAT EMBRYOL CEL, V59, P1, DOI DOI 10.1007/978-3-642-67432-7_1
  • [4] MORPHOLOGY OF BLOOD-BRAIN INTERFACES
    BRIGHTMAN, MW
    [J]. EXPERIMENTAL EYE RESEARCH, 1977, 25 : 1 - 25
  • [5] Dahlborg SA, 1998, CANCER J, V4, P110
  • [6] CHOROID PLEXUS - A HISTORICAL REVIEW
    DOHRMANN, GJ
    [J]. BRAIN RESEARCH, 1970, 18 (02) : 197 - +
  • [7] Blood-brain barrier permeation: Molecular parameters governing passive diffusion
    Fischer, H
    Gottschlich, R
    Seelig, A
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 1998, 165 (03) : 201 - 211
  • [8] Determinants of passive drug entry into the central nervous system
    Habgood, MD
    Begley, DJ
    Abbott, NJ
    [J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2000, 20 (02) : 231 - 253
  • [9] DISTRIBUTION OF NERVE GROWTH-FACTOR FOLLOWING DIRECT DELIVERY TO BRAIN INTERSTITIUM
    KREWSON, CE
    KLARMAN, ML
    SALTZMAN, WM
    [J]. BRAIN RESEARCH, 1995, 680 (1-2) : 196 - 206
  • [10] Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo
    Lee, HJ
    Pardridge, WM
    [J]. BIOCONJUGATE CHEMISTRY, 2001, 12 (06) : 995 - 999