Bone tissue engineering in clinical application - Assessment of the current situation

被引：21

作者：

Bernstein, P. ^{[1
]}

Bornhaeuser, M. ^{[2
]}

Guenther, K. -P. ^{[1
]}

Stiehler, M. ^{[1
]}

机构：

[1] Univ Klinikum Carl Gustav Carus, Orthopad Klin, D-01307 Dresden, Germany

[2] Univ Klinikum Carl Gustav Carus, Med Klin 1, D-01307 Dresden, Germany

来源：

ORTHOPADE | 2009年 / 38卷 / 11期

关键词：

Tissue engineering; Bone defect; Bone transplant; Stem cells; MESENCHYMAL STEM-CELLS; GRAFT SUBSTITUTES; MARROW-CELLS; IN-VITRO; CULTURE; GROWTH; OSTEONECROSIS; STERILIZATION; BIOMATERIALS; IMPLANTATION;

D O I：

10.1007/s00132-009-1493-8

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Treatment of severe bone defects remains a challenge in orthopaedic surgery and traumatology. Surgical techniques should provide primary stability to reach osseous integration and secondary remodeling of bone grafts and substitute materials. None of the currently available substitute materials provides osteoconduction and osteogenesis comparable to those of human allografts and autografts. To enhance osteoinductive and osteogenetic properties of these implants mesenchymal stem cells are used successfully in bone tissue engineering approaches. The aim of this report is to summarize the currently available data on bone tissue engineering and preliminary experience with a tissue engineered graft in acetabular revision surgery after loosening of a hip replacement.

引用

页码：1029 / +

页数：7

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