Regiocontrol in an intramolecular Schmidt reaction:: Total synthesis of (+)-aspidospermidine

被引：93

作者：

Iyengar, R ^{[1
]}

Schildknegt, K ^{[1
]}

Aubé, J ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 11期

关键词：

D O I：

10.1021/ol005913c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A total synthesis of (+)-aspidospermidine (1) is described, featuring an intramolecular Schmidt reaction as the key step. The effects of stereochemistry and protecting group status on the regia and chemoselectivity of this reaction were examined.

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页码：1625 / 1627

页数：3

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