A laser microprobe mass analysis of drain aluminum and iron in dementia pugilistica: Comparison with Alzheimer's disease

被引：92

作者：

Bouras, C

Giannakopoulos, P

Good, PF

Hsu, A

Hof, PR

Perl, DP

机构：

[1] UNIV GENEVA,SCH MED,HUG BELLE IDEE,DEPT PSYCHIAT,CH-1211 GENEVA,SWITZERLAND

[2] CUNY MT SINAI SCH MED,FISHBERG RES CTR NEUROBIOL,NEW YORK,NY 10029

[3] CUNY MT SINAI SCH MED,NEUROBIOL AGING LABS,NEW YORK,NY 10029

[4] CUNY MT SINAI SCH MED,DEPT PATHOL NEUROPATHOL,NEW YORK,NY 10029

[5] CUNY MT SINAI SCH MED,DEPT GERIATR & ADULT DEV,NEW YORK,NY 10029

[6] CUNY MT SINAI SCH MED,DEPT OPHTHALMOL,NEW YORK,NY 10029

来源：

EUROPEAN NEUROLOGY | 1997年 / 38卷 / 01期

关键词：

Alzheimer's disease; dementia pugilistica; laser microprobe mass analysis; trace elements;

D O I：

10.1159/000112903

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer's disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases, High levels of Al and Fe were also detected in the nuclei of NFT-free and NET-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NET contained substantially higher levels of Al and Fe in DP compared to AD cases, These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD.

引用

页码：53 / 58

页数：6

共 49 条

[1] THE CEREBRAL VASCULATURE IN DEMENTIA PUGILISTICA [J].