Global signatures of protein and mRNA expression levels

被引:988
作者
Abreu, Raquel de Sousa [2 ]
Penalva, Luiz O. [2 ]
Marcotte, Edward M. [1 ]
Vogel, Christine [1 ]
机构
[1] Univ Texas Austin, Ctr Syst & Synthet Biol, Inst Cellular & Mol Biol, Austin, TX 78712 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Childrens Canc Res Inst, Houston, TX USA
关键词
GENOME-WIDE ANALYSIS; UBIQUITIN-PROTEASOME SYSTEM; OPEN READING FRAMES; STEM-CELL MARKERS; NF-KAPPA-B; TRANSLATIONAL PROFILING APPROACH; YEAST SACCHAROMYCES-CEREVISIAE; EUKARYOTIC GENE-EXPRESSION; AMYLOID PRECURSOR PROTEIN; INTERNAL RIBOSOME ENTRY;
D O I
10.1039/b908315d
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.
引用
收藏
页码:1512 / 1526
页数:15
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