Global signatures of protein and mRNA expression levels

被引：988

作者：

Abreu, Raquel de Sousa ^{[2
]}

Penalva, Luiz O. ^{[2
]}

Marcotte, Edward M. ^{[1
]}

Vogel, Christine ^{[1
]}

机构：

[1] Univ Texas Austin, Ctr Syst & Synthet Biol, Inst Cellular & Mol Biol, Austin, TX 78712 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Childrens Canc Res Inst, Houston, TX USA

来源：

MOLECULAR BIOSYSTEMS | 2009年 / 5卷 / 12期

关键词：

GENOME-WIDE ANALYSIS; UBIQUITIN-PROTEASOME SYSTEM; OPEN READING FRAMES; STEM-CELL MARKERS; NF-KAPPA-B; TRANSLATIONAL PROFILING APPROACH; YEAST SACCHAROMYCES-CEREVISIAE; EUKARYOTIC GENE-EXPRESSION; AMYLOID PRECURSOR PROTEIN; INTERNAL RIBOSOME ENTRY;

D O I：

10.1039/b908315d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

引用

页码：1512 / 1526

页数：15

共 193 条

[31] microRNAs and muscle disorders [J].

Chen, Jian-Fu ;

Callis, Thomas E. ;

Wang, Da-Zhi .

JOURNAL OF CELL SCIENCE, 2009, 122 (01) :13-20

[32] The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy [J].

Chu, Isabel M. ;

Hengst, Ludger ;

Slingerland, Joyce M. .

NATURE REVIEWS CANCER, 2008, 8 (04) :253-267

[33] Proteolysis: from the lysosome to ubiquitin and the proteasome [J].

Ciechanover, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (01) :79-86

[34] Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting [J].

Ciechanover, Aaron .

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING, 2007, 1116 :1-28

[35] miR-15 and miR-16 induce apoptosis by targeting BCL2 [J].

Cimmino, A ;

Calin, GA ;

Fabbri, M ;

Iorio, MV ;

Ferracin, M ;

Shimizu, M ;

Wojcik, SE ;

Aqeilan, RI ;

Zupo, S ;

Dono, M ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :13944-13949

[36] Dynamic Proteomics of Individual Cancer Cells in Response to a Drug [J].

Cohen, A. A. ;

Geva-Zatorsky, N. ;

Eden, E. ;

Frenkel-Morgenstern, M. ;

Issaeva, I. ;

Sigal, A. ;

Milo, R. ;

Cohen-Saidon, C. ;

Liron, Y. ;

Kam, Z. ;

Cohen, L. ;

Danon, T. ;

Perzov, N. ;

Alon, U. .

SCIENCE, 2008, 322 (5907) :1511-1516

[37] Structure and activity of the internal ribosome entry site within the human p27Kip1 5′-untranslated region [J].

Coleman, Jennifer ;

Miskimins, W. Keith .

RNA BIOLOGY, 2009, 6 (01) :84-89

[38] Toward a protein profile of Escherichia coli:: Comparison to its transcription profile [J].

Corbin, RW ;

Paliy, O ;

Yang, F ;

Shabanowitz, J ;

Platt, M ;

Lyons, CE ;

Root, K ;

McAuliffe, J ;

Jordan, MI ;

Kustu, S ;

Soupene, E ;

Hunt, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9232-9237

[39] FMRP RNA targets: identification and validation [J].

Darnell, JC ;

Mostovetsky, O ;

Darnell, RB .

GENES BRAIN AND BEHAVIOR, 2005, 4 (06) :341-349

[40] Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function [J].

Darnell, JC ;

Jensen, KB ;

Jin, P ;

Brown, V ;

Warren, ST ;

Darnell, RB .

CELL, 2001, 107 (04) :489-499

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