Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells

被引：11

作者：

Montaner, B ^{[1
]}

Pérez-Tomas, R ^{[1
]}

机构：

[1] Univ Barcelona, Dept Biol Cellular & Anat Patol, Canc Cell Biol Res Grp, E-08907 Lhospitalet De Llobregat, Barcelona, Spain

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

apoptosis; caspases; cytochrome c; prodigiosin;

D O I：

10.1111/j.1749-6632.2002.tb04642.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prodigiosin (PG) is an active component of bacterial origin, with reported apoptotic effects. We examined the activation of caspases-9, -8, and -3 in PG-treated Jurkat cells in a dose-response study. These caspases were activated in apoptotic cells, as judged by the appearance of cleavage products from procaspases, and cytochrome c (cyt c) was released to the cytosol. In addition, PG induced the cleavage of poly (ADP-ribose) polymerase (PARP). This study demonstrates that the activation of caspases-9, -8, and -3 mediates PG-induced apoptosis.

引用

页码：246 / 249

页数：4

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