Ketorolac tromethamine and hemorrhage in tonsillectomy: A prospective, randomized, double-blind study

被引:40
作者
Bailey, R
Sinha, C
Burgess, LPA
机构
[1] TRIPLER ARMY MED CTR,DEPT SURG,OTOLARYNGOL SERV,HONOLULU,HI 96859
[2] WOMACK ARMY MED CTR,FT BRAGG,NC
关键词
ketorolac tromethamine; tonsillectomy; hemorrhage; obstructive sleep apnea syndrome;
D O I
10.1097/00005537-199702000-00006
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Ketorolac tromethamine (KT) is a nonsteroidal, antiinflammatory analgesic. Its nonsedating property makes it an attractive analgesic for sleep apnea patients undergoing uvulopharyngopalatoplasty, but its antiplatelet activity makes the potential for postoperative hemorrhage a concern. A prospective, randomized, double-blind study was designed to evaluate the bleeding risk of KT using adult tonsillectomy patients as the model. Patients were randomized into two groups receiving Meperidine (MP) (controls) or KT for the first postoperative day. Posttonsillectomy bleeding rates of 7% (3/43) in the MP group and 18.9% (7/37) in the KT group were demonstrated, but this difference was not statistically significant. The number of HI doses administered had no effect on the incidence of bleeding or the number of cases requiring return to the operative suite for hemostasis. Although this study did not attain statistical significance, the trend towards increased hemorrhage with RT is worrisome. This study and other reports in the literature support the manufacturer's warning that the use of KT is contraindicated in major surgery.
引用
收藏
页码:166 / 169
页数:4
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