Lipotoxicity versus adipotoxicity - The deleterious effects of adipose tissue on beta cells in the pathogenesis of type 2 diabetes

被引：26

作者：

Eldor, Roy ^{[1
]}

Raz, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Univ Hosp, Dept Med, Diabet Res Ctr, IL-91120 Jerusalem, Israel

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2006年 / 74卷

关键词：

lipotoxicity; adipokines; diabetes mellitus type 2; obesity; beta cell;

D O I：

10.1016/j.diabres.2006.06.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes (T2D) is thought to be a culmination of two seemingly distinct processes, insulin resistance and beta cell failure, both of which have been closely linked to obesity. Here, we focus on the various deleterious effects of obesity on the beta cell. Obesity can affect beta cells directly through the influence of elevated levels of free fatty acids (FFA), or remotely through the newly termed group of cytokines that are secreted by adipose tissue-adipokines. The direct effect of free fatty acids, termed lipotoxicity, is thought to be the result of activation of multiple intracellular signals in the beta cell, eventually leading to apoptosis and reduced insulin secretion. The remote effect of obesity is thought to be mediated by adipokines such as TNF-alpha, IL-6, leptin, omentin, visfatin, adipsin, resistin, apelin and retinol binding protein (rbp4). The currently known effects of these adipokines on beta cell function and survival are reviewed here. (c) 2006 Published by Elsevier Ireland Ltd.

引用

页码：S3 / S8

页数：6

共 77 条

[1] Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients [J].

Bajaj, M ;

Suraamornkul, S ;

Hardies, LJ ;

Pratipanawatr, T ;

DeFronzo, RA .

INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 (06) :783-789

[2] Changes in insulin resistance following bariatric surgery and the adipoinsular axis: Role of the adipocytokines, leptin, adiponectin and resistin [J].

Ballantyne, GH ;

Gumbs, A ;

Modlin, IM .

OBESITY SURGERY, 2005, 15 (05) :692-699

[3]

BELTOWSKI J, 2003, MED SCI MONITOR, V9, P55

[4] Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects [J].

Boden, G ;

Chen, XH ;

Kolaczynski, JW ;

Polansky, M .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (05) :1107-1113

[5] Apelin, a newly identified adipokine up-regulated by insulin and obesity [J].

Boucher, J ;

Masri, B ;

Daviaud, D ;

Gesta, S ;

Guigné, C ;

Mazzucotelli, A ;

Castan-Laurell, I ;

Tack, I ;

Knibiehler, B ;

Carpéné, C ;

Audigier, Y ;

Saulnier-Blache, JS ;

Valet, P .

ENDOCRINOLOGY, 2005, 146 (04) :1764-1771

[6] β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[7]

CAMPBELL IL, 1989, J IMMUNOL, V143, P1188

[8]

CAMPBELL IL, 1988, J IMMUNOL, V141, P2325

[9] TNF-ALPHA AND IFN-GAMMA POTENTIATE THE DELETERIOUS EFFECTS OF IL-1-BETA ON MOUSE PANCREATIC-ISLETS MAINLY VIA GENERATION OF NITRIC-OXIDE [J].

CETKOVICCVRLJE, M ;

EIZIRIK, DL .

CYTOKINE, 1994, 6 (04) :399-406

[10] Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion -: Mechanism of action [J].

Chan, CB ;

De Leo, D ;

Joseph, JW ;

McQuaid, TS ;

Ha, XF ;

Xu, F ;

Tsushima, RG ;

Pennefathner, PS ;

Salapatek, AMF ;

Wheeler, MB .

DIABETES, 2001, 50 (06) :1302-1310

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