Toxic properties of Beauveria pigments on erythrocyte membranes

被引：50

作者：

Jeffs, LB

Khachatourians, GG

机构：

[1] Bioinsecticide Research Laboratory, Dept. Appl. Microbiol. and Food Sci., University of Saskatchewan, Saskatoon, Sask. S7N 5A8

来源：

TOXICON | 1997年 / 35卷 / 08期

关键词：

D O I：

10.1016/S0041-0101(97)00025-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Beauveria pigments, tenellin, bassianin and oosporein, all inhibited total erythrocyte membrane ATPase activity in a dose-dependent manner by as much as 50% at 200 mu g/ml. These pigments inhibited Ca2+-ATPases to a greater extent than Na+/K+-ATPase activity. The ATPase inhibitory activity for these pigments was not specific but was probably a consequence of membrane disruption, since pigments all caused alterations in erythrocyte morphology and promoted varying degrees of cell lysis. (C) 1997 Elsevier Science Ltd.

引用

页码：1351 / 1356

页数：6

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