Life after childhood cancer: marriage and offspring in adult long-term survivors - a population-based study in the Piedmont region, Italy

被引:19
作者
Dama, Elisa [2 ]
Maule, Milena M. [2 ]
Mosso, Maria L. [2 ]
Alessi, Daniela [2 ]
Ghisleni, Micaela [2 ]
Pivetta, Emanuele [2 ]
Pisani, Paola [2 ]
Magnani, Corrado [2 ,3 ]
Pastore, Guido [1 ,2 ,4 ]
Merletti, Franco [2 ]
机构
[1] Univ Turin, Childhood Canc Registry Piedmont, Canc Epidemiol Unit, Dept Biomed Sci & Oncol, I-10126 Turin, Italy
[2] S Giovanni Hosp, Childhood Canc Registry Piedmont, Canc Epidemiol Unit, CPO Piemonte,CeRMS, Turin, Italy
[3] Univ Piemonte Orientale, Unit Med Stat & Epidemiol, Novara, Italy
[4] Univ Piemonte Orientale, Div Pediat, Dept Med Sci, Novara, Italy
关键词
childhood neoplasm; fertility; marriage; population-based studies; quality of life; QUALITY-OF-LIFE; ACUTE LYMPHOBLASTIC-LEUKEMIA; ADOLESCENT CANCER; FEMALE SURVIVORS; TIME TRENDS; FERTILITY; RADIOTHERAPY; PROBABILITY; PARENTHOOD; MENOPAUSE;
D O I
10.1097/CEJ.0b013e3283307770
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The majority of childhood cancer cases survive to adulthood. We describe the experience of marriage and reproduction as indicators of quality of life, in a population-based cohort of adult long-term survivors after early cancer reported to the Childhood Cancer Registry of Piedmont The study included 1237 survivors with a malignant neoplasm diagnosed during 1967-2000 when aged 0-14 years, who attained age 18 years. Vital and marital status and number of offspring were assessed through the Vital Statistics Offices. Marriage and fertility deficits were estimated by comparison with the Piedmont population. Among the individuals included in this study, 919 (74.3%) never married and never lived as married. The marriage deficit was 32% [observed/expected 0.68; 95% confidence interval (CI): 0.55-0.831 in men and 18% (observed/expected 0.82; 95% CI: 0.68-0.98) in women. A total of 179 children were born to 120 women, with a fertility deficit of 41% (observed/expected 0.59; 95% CI: 0.51-0.69). In conclusion, the observed decrements in marriage in men and women and fertility in women suggest that efforts should be made to improve the recovery from physical and psychological traumas related to diagnosis and treatment of cancer. European Journal of Cancer Prevention 18:425-430 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码:425 / 430
页数:6
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