Preparation of fluorine-18 labelled sugars and derivatives and their application as tracer for positron-emission-tomography

被引：43

作者：

Beuthien-Baumann, B

Hamacher, K

Oberdorfer, F

Steinbach, J

机构：

[1] Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut Chem, D-01314 Dresden, Germany

[2] Tech Univ Dresden, Klin & Poliklin Nukl Med, D-01307 Dresden, Germany

[3] Forschungszentrum Julich, Inst Nukl Chem, D-52425 Julich, Germany

[4] Radiochem & Isotopentech, D-69121 Heidelberg, Germany

来源：

CARBOHYDRATE RESEARCH | 2000年 / 327卷 / 1-2期

关键词：

positron-emission-tomography; F-18-labelled carbohydrates; medical application;

D O I：

10.1016/S0008-6215(00)00030-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The usefulness of F-18-labelled carbohydrates, especially 2-deoxy-2-[F-18]fluoro-D-gluco se, to study pathophysiological processes in man non-invasively using positron-emission-tomography (PET) led to a widespread investigation of different F-18-labelled sugars and sugar derivatives. In consideration of the short half-life of fluorine-18 (T-1/2 = 110 min) synthetic strategies concerning precursor design, labelling conditions and deprotection of the intermediate compounds were developed to guarantee an efficient high radiochemical yield synthesis for diagnostic purposes. Besides some aspects of medical application of 2-deoxy-2-[F-18]fluoro-D-glucose, a few synthetic strategies are described reflecting development work on promising F-18-labelled sugars for diagnostic purposes during the last two decades. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：107 / 118

页数：12

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