Subthalamic nucleus stimulation in Parkinson disease induces apathy A PET study

被引：154

作者：

Le Jeune, F. ^{[2
,3
]}

Drapier, D. ^{[3
,7
]}

Bourguignon, A. ^{[3
,7
]}

Peron, J. ^{[3
]}

Mesbah, H. ^{[6
]}

Drapier, S. ^{[3
]}

Sauleau, P. ^{[3
,4
]}

Haegelen, C. ^{[3
,5
]}

Travers, D. ^{[3
,7
]}

Garin, E. ^{[2
]}

Malbert, C. H. ^{[8
]}

Millet, B. ^{[3
,7
]}

Verin, M. ^{[1
,3
]}

机构：

[1] CHU Rennes, Hop Pontchaillou, Serv Neurol, Neurol Clin, F-35033 Rennes, France

[2] Ctr Eugene Marquis, Nucl Med Serv, Rennes, France

[3] Univ Rennes 1, CHU Rennes, Unite Rech Univ Comportement & Noyaux Gris Centra, Rennes, France

[4] CHU Rennes, Hop Pontchaillou, Serv Explorat Fonct, F-35033 Rennes, France

[5] CHU Rennes, Hop Pontchaillou, Serv Neurochirurg, F-35033 Rennes, France

[6] Ctr Eugene Marquis, Dept Med Informat, Rennes, France

[7] CH Guillaume Regnier, SHU Psychiat Adulte, Rennes, France

[8] Equipe Control Ingest, UMR SENAH, St Gilles, France

来源：

NEUROLOGY | 2009年 / 73卷 / 21期

关键词：

DEEP BRAIN-STIMULATION; BASAL GANGLIA; EMOTION RECOGNITION; FUNCTIONAL-ANATOMY; CORTEX; DIAGNOSIS;

D O I：

10.1212/WNL.0b013e3181c34b34

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: Apathy may be induced by subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease (PD). We therefore wished to test the hypothesis that apathy induced by STN-DBS correlates with changes in glucose metabolism, using (18)FDG-PET. Methods: Twelve patients with PD were assessed 3 months before (M - 3) and 3 months after (M = 3) STN-DBS with (18)FDG-PET and the Apathy Evaluation Scale. Results: Apathy had significantly worsened at M = 3 after STN-DBS. Positive correlations were observed between this variation in apathy scores and changes in glucose metabolism, especially in the right frontal middle gyrus (Brodmann area [BA] 10) and right inferior frontal gyrus (BA 46 and BA 47). Negative correlations between the two were observed in the right posterior cingulate gyrus (BA 31) and left medial frontal lobe (BA 9). Conclusion: These preliminary results confirm the role of the subthalamic nucleus in associative and limbic circuitry in humans and suggest that it is a key basal ganglia structure in motivation circuitry. Neurology (R) 2009; 73: 1746-1751

引用

页码：1746 / 1751

页数：6

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