Autoimmune T cells in myasthenia gravis: Heterogeneity and potential for specific immunotargeting

被引：51

作者：

Hawke, S

Matsuo, H

Nicolle, M

Malcherek, G

Melms, A

Willcox, N

机构：

[1] UNIV TUBINGEN, NEUROL KLIN, D-72076 TUBINGEN, GERMANY

[2] KAWATANA NATL HOSP, DEPT NEUROL, NAGASAKI 85936, JAPAN

[3] VICTORIA HOSP, DEPT CLIN NEUROL SCI, LONDON, ON N6A 4G5, CANADA

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期

关键词：

D O I：

10.1016/0167-5699(96)10022-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The initiation of many autoimmune and allergic responses depends on specific T cells, which could thus be selectively targeted for potential therapeutic benefit. The target autoantigen of myasthenia gravis (MG) has been identified; however, the heterogeneity among T cells that recognize it is much greater in some reports than in others. Here, Simon Hawke and colleagues discuss how the prospects for specific therapeutic intervention depend on the resolution of this controversy.

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页码：307 / 311

页数：5

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