Neuronal excitability and conduction velocity changes in hippocampal slices from streptozotocin-treated diabetic rats

被引：16

作者：

Candy, SM ^{[1
]}

Szatkowski, MS ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, Sch Med, London SW7 2AZ, England

来源：

BRAIN RESEARCH | 2000年 / 863卷 / 1-2期

关键词：

hippocampus; streptozotocin; neuropathy; excitability; diabetes; conduction velocity;

D O I：

10.1016/S0006-8993(00)02171-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of streptozotocin-induced diabetes on the electrophysiological properties of central neurones were investigated in rat hippocampal slices. No differences in membrane potential, input resistance or action potential parameters could be detected in pyramidal or granule cells. However, a slowing of conduction velocity in granule cells and an increase in excitability of fibre volleys in both the perforant pathway and granule cell mossy fibre projections was observed. The lack of effect on evoked fEPSPs in these pathways is also consistent with diabetes-dependent changes in the voltage-dependence of synaptic strength. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：298 / 301

页数：4

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