N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria

被引：54

作者：

Banaclocha, MM

Hernandez, AI

Martinez, N

Ferrandiz, ML

机构：

[1] UNIV ALICANTE, FAC MED, DEPT FARMACOL & TERAPEUT, E-03080 ALICANTE, SPAIN

[2] GEN HOSP, DEPT ANAT PATOL, ALICANTE, SPAIN

[3] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46010 VALENCIA, SPAIN

来源：

BRAIN RESEARCH | 1997年 / 762卷 / 1-2期

关键词：

aging; synaptic mitochondrion; protein carbonyl; thiol; antioxidant;

D O I：

10.1016/S0006-8993(97)00493-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated the effect of a thiolic antioxidant on protein carbonyl content in synaptic mitochondria from female OF-1 mice. At 48 weeks of age, a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant decrease in protein carbonyl content in synaptic mitochondria of the N-acetylcysteine-treated animals as compared to age-matched controls. (C) 1997 Elsevier Science B.V.

引用

页码：256 / 258

页数：3

共 24 条

[1] THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID [J].